Stéphane Guillarme

Stéphane Guillarme is a Lecturer at the Chemistry Department of the University Institute of Technology of Le Mans (IUT du Mans), affiliated with Le Mans University. He conducts research at the IMMM Laboratory (UMR CNRS 6283) within the Faculty of Sciences. He obtained his doctorate in Fine Chemistry/Organic Chemistry from the University of Maine, Le Mans, in 2002, and completed his Habilitation (HDR) in 2017 on "Carbohydrates for asymmetric catalysis and the synthesis of bioactive molecules".

Teaching Activities

• Head of the Professional License in Fine Chemistry and Synthesis (LPCF)
• Analytical Chemistry: Courses (Separative Methods), Tutorials and Practicals (DUT, LPAC)
• Organic Chemistry: Tutorials and Practicals (DUT and LPCF)
• Solvents, Green Chemistry and non-standard media (LPCF)
• Glycochemistry and Nucleosides (M2 Chemistry)
• Green Chemistry (M2 Chemistry)

Research Focus

His research encompasses organic synthesis with emphasis on:

• Novel methodologies for C-glycoside synthesis targeting bioactive molecules
• Development of chiral ligands from carbohydrates for asymmetric catalysis
• Organocatalytic approaches
• Synthesis of glycosylceramide analogues and constrained ceramides

Key areas include dianhydroglycitols, glycochemistry, and the design of immunologically active compounds.

Publication Trends

Analysis of recent publications (2008–2020) reveals consistent focus on stereoselective C-glycoside synthesis, asymmetric catalysis using carbohydrate-derived ligands, organocatalysis, and development of bioactive molecules. His work frequently employs cycloadditions, organometallic reactions, and innovative strategies for carbohydrate functionalization, with applications in medicinal chemistry.

Patents and Books

• Co-inventor of patent: "C-Glycoside analogues of alpha-galactosylceramides having immunostimulating properties" (WO2010/049451)
• Authored book chapters on polymer-supported nitrogen ligands for asymmetric catalysis (2010)

Affiliations

Primary research is conducted at IMMM Laboratory (UMR CNRS 6283), specializing in organic synthesis and material science, with collaborations spanning medicinal chemistry and catalysis groups.