Srigokul Upadhyayula

Srigokul Upadhyayula is an Assistant Professor in Residence in the Department of Molecular and Cell Biology at the University of California, Berkeley. He serves as the Scientific Director of the Advanced Bioimaging Center (ABC) and is a Chan Zuckerberg Initiative Imaging Scientist. His work bridges applied engineering with basic science, focusing on developing cutting-edge imaging technologies like the Adaptive Optical Multi-functional Lattice Light-Sheet Microscope. The ABC specializes in handling tera- to petabyte-scale imaging data, integrating artificial intelligence to analyze complex datasets and advance both fundamental and translational research.

• Academic Role: Assistant Professor in Residence
• Directorships: Advanced Bioimaging Center, CZI Imaging Scientist

Research interests center on optical imaging systems, high-resolution microscopy, and computational workflows for biological data analysis. Key projects include multi-scale imaging across millimeter-scale specimens and long-term imaging sessions, emphasizing the synergy between advanced microscopy and AI-driven data interpretation.

Publications highlight breakthroughs in lattice light-sheet microscopy, clathrin-mediated endocytosis, and mitochondrial dynamics. His work has been featured on Science and eLife covers, underscoring contributions to cellular and developmental biology.

Advising and grants involve leading interdisciplinary teams to develop imaging infrastructure and computational tools. The ABC aims to democratize access to advanced imaging through open-source workflows.

Laboratory initiatives include the ABC’s global imaging initiative, combining hardware innovation with AI to solve complex biological questions.