معرفی
Sreeganga Chandra is an Associate Professor in the Departments of Neurology and Neuroscience at the Yale School of Medicine. Her research focuses on synaptic biology and neurodegeneration, particularly Parkinson’s disease (PD) and neuronal ceroid lipofuscinosis (NCL). She investigates how disruptions in synaptic proteostasis contribute to these disorders. Key areas include synapse maintenance mechanisms, presynaptic dysfunction, and the role of proteins like α-synuclein and CSPα. Chandra’s lab employs mouse models, human iPSC-derived neurons, and advanced techniques like proteomics and functional imaging. Notable findings include the identification of synaptic vesicle sorting defects in PD and the role of auxilin in disease progression. She has been recognized for contributions to understanding olfactory deficits in PD and the interplay between endolysosomal pathways and neurodegeneration. Chandra holds a PhD in Chemistry from Purdue University and completed postdoctoral training with Thomas C. Südhof.
