معرفی
Sourav Ghosh, Ph.D., is a Professor in the Department of Neurology and Associate Professor in Pharmacology at Yale School of Medicine. He is co-director of a research laboratory with Dr. Carla Rothlin, focusing on the molecular regulation of inflammation. His work is affiliated with the Interdepartmental Neuroscience Program, Yale Cancer Center, and the Program for Neuroinflammation.
- Ph.D., University of Tennessee, Molecular Sciences (2000)
- M.Sc., University of Calcutta, Zoology (1992)
- Postdoctoral Fellowship, Salk Institute for Biological Studies
Dr. Ghosh's research centers on the negative regulation of inflammation, particularly through pathways like TAM receptors (Tyro3, Axl, Mer), efferocytosis, and immune checkpoint mechanisms. His studies explore how dysregulation of these processes contributes to chronic inflammation, autoimmunity, cancer, and neurodegenerative diseases. He investigates the 'Goldilocks Principle' of immune response—ensuring inflammation is neither too weak nor too strong.
His recent publications span top journals including Nature, Science, Cell, and Nature Immunology, with key themes in dendritic cell immunometabolism, senescence and efferocytosis, neuroinflammation, and epigenetic regulation in the nervous system. His work increasingly bridges immunology, neuroscience, and cancer biology.
- Cholesterol mobilization in dendritic cells and anti-tumor immunity
- Senescent cell suppression of efferocytosis in aging
- Retinal inflammation in Mertk-associated retinitis pigmentosa
- Stem cell regulation of tissue fitness via dead cell clearance
- Epigenetic control of PKMζ in brain function
Dr. Ghosh has collaborated extensively with Dr. Carla Rothlin, Dr. Joseph Craft, and others across Yale. His lab contributes to interdisciplinary programs in neuroinflammation and cancer signaling. While specific grant details are not provided, his high-impact publications suggest significant research funding. He is actively involved in mentoring and training within the Yale Combined Program in the Biological and Biomedical Sciences (BBS).
His laboratory is located at the Anlyan Center, 300 Cedar Street, New Haven, CT.
