معرفی
Simon Bullock is a Research Fellow at the MRC Laboratory of Molecular Biology (University of Cambridge), specializing in the molecular cell biology of cytoskeletal transport. His work investigates how motor proteins like dynein and kinesin recognize and deliver diverse cargoes (mRNAs, vesicles, organelles) to specific cellular destinations.
- Research Focus: Mechanisms of motor-cargo recognition, coordination of multiple motors on single cargoes, regulation of transport by extrinsic cues, and links to neurodegeneration.
- Methods: Drosophila genetics, in vivo imaging, biochemistry, structural biology, and single-molecule in vitro transport assays.
Recent studies highlight his contributions to understanding dynein's role in mitotic progression, RNA transport coordination via tropomyosin, and genome-wide CRISPR screens identifying transport regulators. His work also explores how C9orf72-derived dipeptide repeats disrupt axonal transport in neurodegenerative diseases.
Simon Bullock's group members include Lucas Albacete, Sabila Chilaeva, Li Jin, and others. His research bridges fundamental cellular mechanisms to human disease implications, particularly in neurological disorders.
