معرفی
Dr. Shu-Yuan Yeh is a Professor in the Department of Urology at the University of Rochester School of Medicine and Dentistry. With over 78 peer-reviewed publications and 17 review articles, her research has significantly advanced our understanding of hormone receptor signaling in urological diseases. Her laboratory has pioneered innovative approaches using genetically engineered mouse models to study androgen and estrogen receptor functions.
Dr. Yeh's educational background includes a PhD in Endocrinology/Molecular Oncology from the University of Wisconsin-Madison (1996), an MS in Biochemical Science from National Taiwan University (1991), and a BS in Medical Biotechnology/Immunology from National Taiwan University (1988). Her research program has been consistently funded by prestigious organizations including the National Cancer Institute and the Department of Defense.
Her primary research focuses on the roles of estrogen receptor (ER) and androgen receptor (AR) in urological diseases, particularly prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH), and male fertility. Dr. Yeh was the first scientist to clone AR-associated protein in 1996 and to create AR knockout (ARKO) mice using the cre-loxP strategy in 2002. Her lab has established genetically engineered ERalpha knockout (ERaKO) mice and identified new ER binding proteins and target genes involved in disease progression.
Analysis of her recent publications reveals a strong emphasis on cancer stem cells, non-coding RNA regulation, and the tumor microenvironment's role in urological cancers. Her work demonstrates how hormone receptors interact with various signaling pathways to influence cancer progression, treatment resistance, and metastasis. She has made significant contributions to understanding how AR and ER signaling differs across tissue types and how this knowledge can be leveraged for therapeutic development.
Dr. Yeh's scientific achievements have been recognized with numerous awards including multiple AUA Best Poster awards (2019, 2007), SBUR Best Poster award (2012), Outstanding Young Investigator Award (2001), NIH Postdoctoral Fellowship (1999), and multiple CaPCURE Research Awards (1995-1996).
Her research has led to important patents, including the creation of female mice without androgen receptor, and has resulted in multiple book chapters on androgen and estrogen receptor functions in prostate development and cancer. Dr. Yeh continues to advance the field with innovative approaches to targeting hormone receptor signaling pathways for improved cancer treatment.
