معرفی
Shohreh Amini is a Professor in the Department of Biology at Temple University, serving as Director of the PSM program in Biotechnology and President of the Temple Faculty Senate. Her primary research focuses on molecular mechanisms of HIV-1-induced neurological dysfunction, including viral-host interactions in the brain, mitochondrial damage, and neuroinflammatory pathways. She also investigates fetal alcohol spectrum disorders (FASD) using advanced models and biomarker discovery, particularly through exosomal miRNA and lipid profiling.
Research interests span molecular virology, neurodegeneration, and translational medicine. Notable work includes CRISPR-based HIV cure strategies, mitochondrial dysregulation in neuroAIDS, and developmental neurotoxicity mechanisms. Her studies often integrate cell culture systems (primary neurons, astrocytes), in vivo models, and advanced genomic techniques like RNA sequencing.
Key contributions include identifying exosomal biomarkers for FASD diagnosis and elucidating HIV-1 Tat protein's role in lipid homeostasis disruption. She has pioneered methods for isolating brain microvascular endothelial cells and characterizing neuronal BAG3 protein's role in synaptic vesicle dynamics.
Recent publications emphasize CRISPR editing of viral reservoirs, mitochondrial DNA repair inhibition by ethanol, and novel therapeutic targets for neuroAIDS. Her research bridges basic science and clinical applications, with focus on biomarker development and antiviral strategies.
