معرفی
Dr. Shiny Nair is a Research Scientist at the Yale School of Medicine, affiliated with the Department of Medicine (Digestive Diseases) and Internal Medicine. She holds a PhD from Manipal University (2010) and an MSc from the University of Pune (2004). Her research focuses on understanding how lysosomal storage diseases like Gaucher disease contribute to immune dysregulation and increased cancer risk, particularly multiple myeloma and hepatocellular carcinoma. Her work integrates molecular, cellular, and genetic approaches to uncover disease mechanisms and therapeutic targets.
Key research interests include the immune mechanisms linking Gaucher disease to cancer, neuroinflammation in neuronopathic Gaucher disease, and genomic studies of disease phenotypic diversity. Collaborations with Dr. Pramod Mistry, Dr. Jeff Ruan, and others have led to significant findings on bone marrow microenvironment dysregulation, brain cell atlas analysis, and mouse model development. Recent studies highlight the Apoe-Abca1 axis in Gaucher pathogenesis and the role of microglia/NK cells in neurodegeneration.
Publications (2013–2025) span topics like monoclonal gammopathy origins, NKT cell immunotherapy, and SARS-CoV-2 infection in immunocompromised patients. Her work emphasizes translational research bridging rare and common diseases.
