معرفی
Sheena Radford serves as the Astbury Professor of Biophysics and Director of the Astbury Centre for Structural Molecular Biology at the University of Leeds' Faculty of Biological Sciences. With over 30 years of academic leadership, she heads a research group comprising 15 PhD students and 10 postdoctoral researchers, while directing the Astbury Society (70 PIs, 400 members).
Her research focuses on fundamental structural molecular biology, specifically investigating protein folding/misfolding mechanisms that cause fatal human diseases, and outer membrane protein assembly in Gram-negative bacteria for antibiotic resistance targeting. Utilizing advanced biophysical techniques including native mass spectrometry, HX-MS, ion mobility MS, NMR, cryo-EM, and single-molecule methods, her work bridges basic science and therapeutic development.
Analysis of her 310+ publications reveals dominant research themes in amyloid formation (40% of recent work), membrane protein biogenesis (30%), and biophysical method development (30%), with strong translational focus on neurodegenerative diseases and antibiotic resistance.
- Fellow of the Royal Society (FRS)
- ERC Advanced Grant recipient (€2.49M)
- Royal Society of Chemistry Astra-Zeneca Prize
- Protein Society Carl Branden Award
- Over 19,450 citations (h-index 76)
Professor Radford has supervised 86 PhD students and 56 postdocs, secured £65M+ in career grant funding, and organized 5 major international conferences including the 2019 Protein Society Symposium in Seattle. Her laboratory maintains active collaborations with 12 international institutions and leads the BAM complex research consortium targeting novel antibiotic development.
