جستجوی استاد راهنمای دانشگاهی

Dr. Jose Perdomo is a Research Fellow at the Central Clinical School, Sydney Medical School, within the Faculty of Medicine and Health at the University of Sydney. He is based at the Charles Perkins Centre, where his research focuses on endothelial damage, immune complex-driven thrombosis, and platelet formation mechanisms. His work employs techniques such as flow cytometry, microfluidics, and intravital microscopy. Dr. Perdomo holds a PhD from the University of Sydney’s School of Molecular and Microbial Biosciences and received a Vice-Chancellor’s Fellowship. His research has led to two international patents and recognition, including 1st prize in the 2020 China Shenzhen Innovation Competition. His studies explore targeted inhibitors to prevent immune complex formation and thrombosis, with applications in cardiovascular health. His research interests include the interplay between white blood cells, endothelial cells, and platelets, with a focus on desialylation, apoptosis, and NETosis in immune thrombocytopenia. He has contributed to understanding vaccine-induced immune thrombocytopenia and thrombotic complications post-myocardial infarction. His findings have been featured in Nature Communications , Blood Advances , and other high-impact journals. Awards: 1st prize in China Shenzhen Innovation Competition (2020). Labs/Teams: Charles Perkins Centre, University of Sydney. Grants: Vice-Chancellor’s Fellowship (University of Sydney). Media Contributions: Insights into AstraZeneca vaccine-related blood clots featured in The Guardian , SMH , and ABC News.

• Thrombosis
• Hematology
• Immunology
• +۳ مورد دیگر

Overview Sebastian Schuck is a Professor of Biochemistry and Molecular Cell Biology at Heidelberg University's Biochemistry Center (BZH). His research focuses on organelle homeostasis, particularly the endoplasmic reticulum (ER), with emphasis on ER membrane biogenesis, ER-phagy, and SHRED pathways. He leads an international team investigating how cells adapt ER structure and function under stress or disease conditions. Education & Career Since 2021: Professor at Heidelberg University BZH 2013–2021: Independent Group Leader at Heidelberg University's Center for Molecular Biology 2006–2013: Postdoc with Peter Walter at UCSF 2001–2006: PhD and Postdoc with Kai Simons at Dresden's Max Planck Institute 1995–2000: Biochemistry studies at Universities of Hannover and Tübingen Research Interests Dr. Schuck's lab explores molecular mechanisms underlying ER homeostasis, including: 1. ER expansion during stress via lipid synthesis 2. Microautophagy-mediated ER degradation via ESCRT machinery 3. SHRED pathway regulation of proteasomal degradation of misfolded proteins 4. Links between ER stress and neurodegenerative diseases/cancer Awards & Honors No specific awards listed, but recognized for pioneering contributions to understanding microautophagy and ER quality control mechanisms. Advising & Collaborations Advised over 20 PhD/Master's students and postdocs Collaborations with Carlos Bas-Orth (MPI Biochemistry), Liam Holt (NY), and others Labs & Teams Current lab includes 10+ members focusing on: - Human ER morphogenesis - Microautophagy dynamics - SHRED pathway mechanisms

• Cell Biology
• Molecular Biology
• Membrane Biology
• +۴ مورد دیگر

Prof. Dr. Markus Meissner is a Professor at the Faculty of Veterinary Medicine, Ludwig Maximilian University of Munich, leading the Chair of Experimental Parasitology. His research focuses on the molecular mechanisms of host cell invasion and modulation by Apicomplexan parasites, particularly Toxoplasma gondii and Plasmodium species. Research Group: Meissner Laboratory Location: Lena-Christ-Str. 48, 82152 Planegg-Martinsried Contact: markus.meissner@lmu.de His work investigates the secretory pathway of parasites, vesicular trafficking systems, and essential genes involved in host cell invasion and intracellular development. Toxoplasma gondii serves as a model organism for studying Apicomplexan biology, including nuclear division and CRMP complex functionality. Recent publications highlight the role of Rab GTPases in protein trafficking, chromatin remodeling in Plasmodium, and actin dynamics in parasite motility. Articles span topics such as egress factors, Golgi pathways, and lineage-specific organelle emergence, reflecting a multidisciplinary approach combining molecular biology, cell biology, and evolutionary analysis. The Meissner Lab includes PhD students (Peipei Qin, Yuan Song, Ella Schadt, Vitoria Catschor dos Santos) and postdocs (Dr. Wei Li, Dr. Miriam Rafajlovic). Research is conducted in Lena-Christ-Str. 48, Planegg-Martinsried, with a focus on experimental systems for studying parasite mechanisms.

• Apicomplexan Parasites
• Host Cell Invasion
• Vesicular Trafficking
• +۳ مورد دیگر

James C. Gumbart is an Adjunct Professor in the School of Physics at Georgia Institute of Technology, with additional affiliation to the School of Chemistry and the Institute for Bioengineering and Bioscience . His research leverages molecular dynamics simulations to decode the atomic-level mechanisms of bacterial proteins and cellular structures. B.S., Physics and Mathematics, Western Illinois University, 2003 Ph.D., Physics, University of Illinois at Urbana Champaign, 2009 Dr. Gumbart's work bridges computational biophysics and biochemistry to understand: Mechanisms of bacterial membrane protein insertion and nutrient import Structural dynamics of cell wall mechanics SARS-CoV-2 spike protein interactions with ACE2 Free-energy calculations for protein-ligand binding Applications of machine learning in biomolecular simulations His publications reflect trends in membrane protein biophysics , viral dynamics , and computational drug design , with a strong emphasis on interdisciplinary techniques. Awards include multiple fellowships and grants from NSF , DOE , and NIAID . He has mentored numerous PhD students, including Zijian Zhang , David Ryoo , and Andrew Pang , whose work has advanced understanding of bacterial systems and viral proteins. The Gumbart Lab integrates high-powered supercomputing and advanced software to model biomolecular processes, fostering collaborations with institutions like the National Institutes of Health and Argonne National Laboratory .

• Computational Biochemistry and Biophysics
• Membrane proteins
• Free-energy calculations
• +۷ مورد دیگر

Clifford P. Brangwynne is the June K. Wu '92 Professor of Chemical and Biological Engineering and Bioengineering at Princeton University, serving as Director of the Omenn-Darling Bioengineering Institute. His research bridges biophysics, bioengineering, and cell biology to investigate the physical principles governing intracellular organization through liquid-liquid phase separation. Education Ph.D. in Applied Physics, Harvard University (2007) B.S. in Materials Science and Engineering (minor in Physics), Carnegie Mellon University (2001) Research Focus Brangwynne's lab pioneers the study of membrane-less organelles (biomolecular condensates) formed via phase separation, exploring their roles in nuclear architecture, genome regulation, and disease mechanisms. His work integrates soft matter physics with advanced cell biology to uncover how these condensates form, function, and contribute to pathological protein aggregation in neurodegenerative disorders, while developing synthetic organelle engineering for biomedical applications. Publication Trends His publications consistently demonstrate how liquid phase condensation governs cellular organization across scales—from nuclear genome restructuring to pathological aggregation. The interdisciplinary approach reveals fundamental physical principles while driving technological innovations in organelle engineering and disease modeling. Major Awards Breakthrough Prize for Life Sciences (2023) Raymond and Beverly Sackler International Prize in Biophysics (2023) Tsuneko & Reiji Okazaki Award (2021) Wiley Prize in Biomedical Sciences (2020) Blavatnik National Award in Life Sciences (2020) Human Frontier Science Program Nakasone Award (2020) Michael and Kate Bárány Award, Biophysical Society (2020) HHMI Transformative Technology Award (2019) MacArthur Fellow (2018) HHMI, Simons Foundation, and Bill & Melinda Gates Foundation Faculty Scholar (2016) SCB Gibco Emerging Leader Prize, American Society of Cell Biology (2015) Sloan Research Fellowship (2014) NSF CAREER Award (2013) NIH New Innovator Award (2012) Searle Scholar Award (2012) Helen Hay Whitney Fellow (2008-2010) Advising and Funding He mentors graduate students including Jordy Botello, Yi-Che (Eje) Chang, Yoonji Kim, Claire Weaver, Lennard Wiesner, and Jessica Zhao. Research is supported by HHMI, Simons Foundation, Bill & Melinda Gates Foundation, NIH, NSF, and the Human Frontier Science Program. Laboratory and Collaborations Leading the Soft Living Matter Group, Brangwynne collaborates with theorists including Mikko Haataja (Princeton Mechanical Engineering), Ned Wingreen (Princeton Molecular Biology), and Rohit Pappu (WUSTL), while contributing to the NIH 4D Nucleome Consortium to advance understanding of nuclear organization.

• Biophysics
• Bioengineering
• Soft Matter Physics
• +۳ مورد دیگر

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

• Plant Molecular Biology
• Chloroplast Biology
• Organelle Biotechnology
• +۷ مورد دیگر

Professor Trevor Lithgow is a Research Professor in Microbiology at Monash University, affiliated with the Monash Biomedicine Discovery Institute. He holds a PhD from La Trobe University (1992) and has held fellowships including the ARC Federation Fellowship (2008) and ARC Laureate Fellowship (2014). His research focuses on bacterial cell biology, antimicrobial resistance (AMR), and phage therapies, leveraging nanoscale imaging techniques like cryo-EM and super-resolution microscopy. He leads the Monash Centre to Impact AMR, an interdisciplinary initiative addressing global AMR challenges through collaborations across engineering, social sciences, and clinical medicine. Key achievements include the HFSP Tenth Anniversary Award (1999), Lemberg Medal (2020), and Royal Society of Victoria Medal (2017). His work on bacterial outer membrane assembly, phage-bacteria interactions, and structural analysis of the mitochondrial TOM complex has advanced understanding of pathogen resilience and novel antimicrobial strategies. Current projects include developing phage therapies and cross-sectoral AMR surveillance frameworks. Education: PhD in Biochemistry (La Trobe University, 1992) Research Interests: Bacterial cell surface visualization, nanoscale imaging, phage biology, AMR mechanisms Leadership: Director of Monash Centre to Impact AMR since 2020 Awards: 10+ national/international honors, including ARC Fellowships Publications span over 250 articles on bacterial membrane biology, AMR dynamics, and phage applications, with recent focus on polymyxin dependence in Acinetobacter and phage-driven resistance resensitization.

• Antimicrobial Resistance
• Bacterial Cell Biology
• Membrane Biochemistry
• +۵ مورد دیگر

Michael J. Ragusa is an Associate Professor of Chemistry at the Department of Chemistry, College of Arts and Sciences, Dartmouth College , specializing in molecular mechanisms of selective autophagy . His research integrates structural biology , biochemical reconstitution , and cell biology to understand how cells degrade toxic components like damaged organelles. Education: B.S. in Chemistry from Siena College, Ph.D. in Biochemistry from Brown University His work focuses on autophagy , particularly the role of Atg proteins in membrane tethering and cargo selection. His lab has published extensively on mitophagy , ALFY , and Atg11 , linking defects in these pathways to cancer , neurodegeneration , and infectious diseases . Recent studies highlight mechanisms of vesicle clustering and dimerization-dependent membrane interactions . Dr. Ragusa teaches courses such as CHEM 5: General Chemistry , CHEM 42: Biological Chemistry II , and CHEM 95.05: Protein Crystallography . His lab employs techniques like X-ray crystallography , NMR spectroscopy , and membrane reconstitution to dissect protein-lipid interactions.

• Structural Biology
• Biochemical Reconstitution
• Autophagy
• +۵ مورد دیگر

Lan Guan is a Professor at Texas Tech University Health Sciences Center in the Department of Cell Physiology and Molecular Biophysics within the School of Medicine. He also serves as Co-Director of the Center for Membrane Protein Research. His research focuses on membrane proteins, which constitute approximately 30% of all eukaryotic proteins and play crucial roles in many aspects of cell function. Dr. Guan's research seeks to understand the mechanisms of solute transport and lay the foundation for advances in disease treatment and human health. He employs an integrated approach including cryo-EM single-particle analysis, X-ray crystallography, ligand binding, molecular dynamics simulations, thermodynamics, genetic engineering, novel amphiphiles, and many other biochemical & biophysical analyses. His current research focuses on cation-coupled bacterial and human transporters. Dr. Guan is currently supported by an NIGMS MIRA R35 Award (2024). His publication record demonstrates expertise in membrane protein structure and function, particularly with melibiose transporters (MelB) and their mechanisms. His work spans structural biology, biochemistry, and biophysics, with significant contributions to understanding membrane transport mechanisms. His research has led to important insights into membrane protein structure-function relationships, particularly in sugar transporters. Dr. Guan's work has implications for understanding fundamental biological processes and potential therapeutic applications related to membrane transport. NIGMS MIRA R35 Award 2024 Dr. Guan actively collaborates with researchers across disciplines and institutions, as evidenced by his extensive publication record with numerous co-authors. His work bridges structural biology, biochemistry, and biophysics to advance our understanding of membrane protein function. He is affiliated with the Center for Membrane Protein Research, where he contributes to advancing methodologies for studying these challenging but critically important biological molecules. His work on novel amphiphiles and detergent design has helped overcome technical barriers in membrane protein research.

• Membrane transport
• Membrane proteins
• Solute transport mechanisms
• +۶ مورد دیگر

Peter Chien is an Adjunct Professor in the Department of Biochemistry and Molecular Biology at the University of Massachusetts Amherst. His research focuses on regulated protein degradation and quality control in bacteria, with a particular emphasis on mechanisms governing proteolysis during the bacterial cell cycle. PhD, University of California, San Francisco Postdoctoral Training, Massachusetts Institute of Technology The Chien Lab employs interdisciplinary approaches including biochemistry, structural biology, and cell biology to study proteolytic mechanisms in Caulobacter crescentus. Their work explores how AAA+ proteases like ClpXP and Lon recognize substrates with precision and how this impacts cellular regulatory networks. Recent research trends from the lab include investigations into Lon protease modulation , DNA damage responses , protein homeostasis under stress , and genetic regulators of proteostasis . Studies often integrate structural analysis with functional assays to uncover molecular principles of protease specificity. The lab is affiliated with multiple graduate programs, including the Molecular and Cellular Biology (MCB) program, Chemistry-Biology Interface Program, Biotechnology Training Program, and the Institute for Applied Life Sciences at UMass Amherst.

• Regulated Proteolysis
• Protein Quality Control
• Bacterial Cell Cycle Regulation
• +۴ مورد دیگر

Prof. Dr. Nils Kröger serves as Chair for "Biomimetic Materials" at the Technical University of Dresden, Germany, where he leads the Kröger Group dedicated to studying diatoms and their remarkable biological capabilities. His research program investigates two extraordinary phenomena exhibited by these microalgae: silica biomineralization and underwater adhesion. Academic Background: Diploma in Chemistry, University of Regensburg, Germany (1991) PhD in Biochemistry, University of Regensburg, Germany (1995) Habilitation in Biochemistry, University of Regensburg, Germany (2001) Assistant Professor, Georgia Institute of Technology, Atlanta, USA (2005) Associate Professor, Georgia Institute of Technology, Atlanta, USA (2011) W3 Professor for Biomimetic Materials, TU Dresden, Germany (2012) Professor Kröger's research sits at the intersection of biology, materials science, and nanotechnology. His group employs biochemical, molecular genetic, and cell biological approaches to unravel how diatoms construct intricate silica structures and adhere to surfaces underwater. This work has significant implications for developing novel bio-inspired materials and understanding fundamental biological processes. Recent advancements in his laboratory have revealed molecular mechanisms behind diatom motility and the precise control of silica pattern formation. Analysis of Professor Kröger's publication record shows consistent focus on diatom biology with increasing interdisciplinary collaboration. His recent work demonstrates sophisticated integration of physics, engineering, and biology to understand the mechanical aspects of diatom movement and structure formation. The research shows progression from basic protein characterization to complex systems-level understanding of diatom motility and morphogenesis. Current Research Funding: Deutsche Forschungsgemeinschaft (DFG): PoL Nucleation grant with Prof. Stefan Diez (2022-2025) - Acto-myosin cooperativity and regulation underlying diatom gliding motility Deutsche Forschungsgemeinschaft (DFG) (2018-2022) - Molecular basis of diatom adhesion and motility Previous funding from Air Force Office of Scientific Research (AFOSR) (2010-2016) - Molecular Mechanism of Diatom Adhesion Professor Kröger actively mentors PhD students and maintains a vibrant research group comprising senior scientists, postdoctoral researchers, technicians, and graduate students. His laboratory serves as a hub for interdisciplinary collaboration, bridging traditional boundaries between biology, chemistry, physics, and materials science. The group maintains strong international connections and participates in numerous collaborative research initiatives focused on biomineralization and bio-inspired materials.

• Biomineralization
• Bioadhesion
• Bio-inspired Materials
• +۶ مورد دیگر

Dr. Ahna Skop is a Professor in the Department of Genetics at the University of Wisconsin–Madison. Her research focuses on the molecular mechanisms underlying cell division, particularly the role of midbody remnants and extracellular vesicles in RNA localization and translation. She is also a pioneer in integrating scientific art to enhance public engagement and promote diversity and inclusion in STEM. BS in Biology, Syracuse University PhD in Cell and Molecular Biology, University of Wisconsin–Madison Postdoctoral Fellowship, University of California-Berkeley Her work spans cell biology, developmental biology, and science communication, with recent studies exploring midbody remnant functions in mitosis and strategies for inclusive science education. She leads the Skop Lab, which develops protocols for isolating and imaging extracellular vesicles. Her research on midbody remnants highlights their roles in RNA assembly, localized translation, and potential therapeutic applications. She actively advocates for diversity and inclusion in scientific communities through outreach programs.

• Cell Division
• Molecular Biology
• RNA Biology
• +۳ مورد دیگر

Professor Sebastian Hiller is a Full Professor at the Biozentrum of the University of Basel, Switzerland, where he leads a research group focused on structural biology and biophysics. His laboratory specializes in using nuclear magnetic resonance (NMR) spectroscopy to elucidate the structures and functions of proteins and their interactions at the atomic level. His research spans several key areas including molecular chaperones and protein folding mechanisms, outer membrane protein biogenesis in bacteria, and kinase signaling pathways. Notably, his group has made significant contributions to understanding how chaperones like trigger factor function, the mechanisms of outer membrane protein assembly through the Bam complex, and dynamic kinase interactions. Their work has direct implications for neurodegenerative diseases and antibiotic development. The Hiller lab's recent publications demonstrate a strong focus on NMR methodology development, protein folding dynamics, and structural mechanisms of antibiotic action. Their research on darobactin's mechanism of action against Gram-negative bacteria represents a significant advance in antibiotic discovery. The group frequently publishes in high-impact journals including Nature, Science, and Nature Communications. ICMRBS Founder's Medal (2018) EMBO Young Investigator (2014) ERC starting grant (2011) SNSF professorship (2010) SNSF scholarship for young researchers (2008) Professor Hiller supervises numerous PhD students and postdoctoral researchers, with many alumni having secured prestigious positions in academia and industry. His laboratory maintains strong collaborations across multiple institutions and has received significant funding through ERC grants and other competitive mechanisms. The Hiller group also operates advanced NMR facilities that serve the broader research community at the University of Basel.

• Structural Biology
• NMR Spectroscopy
• Protein Folding
• +۴ مورد دیگر

Ramanujan Hegde serves as a Professor and Group Leader at the MRC Laboratory of Molecular Biology (LMB), University of Cambridge, where he directs research on membrane protein biosynthesis and cellular quality control mechanisms. His work examines how membrane proteins are accurately targeted to organelles, inserted into lipid bilayers, folded, and assembled into functional complexes, with emphasis on the cellular pathways that eliminate defective proteins to prevent disease. Professor Hegde's research program focuses on fundamental questions in cell biology: How do cells ensure precise membrane protein localization? What molecular machinery governs protein insertion and folding? How do quality control systems detect and degrade misfolded proteins? His investigations reveal that biosynthetic failures are common, triggering degradation pathways linked to diseases like neurodegeneration. Key research areas include: Intramembrane chaperone mechanisms for multipass membrane proteins Orphan subunit recognition during complex assembly Ribosome-associated mRNA degradation in autoregulation Proteasome assembly quality control ER membrane protein complex functions Molecular basis of protein aggregation diseases His 2017-2023 publications in Cell, Nature, and Science demonstrate consistent innovation in protein quality control, with landmark discoveries including UBE2O's role in orphan subunit degradation, the EMC as a transmembrane domain insertase, and TTC5-mediated tubulin autoregulation. These works bridge basic cell biology with disease mechanisms through rigorous biochemical and structural approaches. Professor Hegde mentors a research team of 11 scientists: Christine Desroches Altamirano Zhong Yan Gan Dino Janssen Ryan Judy Jennifer Miao Elizabeth Miller Tim Stevens Julia Toplak Huping Wang Haoxi Wu Eszter Zavodszky His laboratory operates within the MRC LMB's world-class infrastructure, utilizing advanced techniques in biochemistry, structural biology, and cell imaging. Supported by Medical Research Council funding, the group maintains strong collaborations across Cambridge and internationally to dissect protein biogenesis pathways with implications for therapeutic development in protein-misfolding disorders.

• Cell Biology
• Molecular Biology
• Membrane Proteins
• +۳ مورد دیگر

Gilles Hickson is a Full Professor at the Université de Montréal’s Faculty of Medicine, Department of Pathology and Cell Biology. He is affiliated with the Azrieli Research Center at CHU Sainte-Justine and serves as Deputy Director of Academic Affairs, Co-director of the Microscopy Imaging Platform, and responsible for the Molecular Biology Program. His research focuses on understanding molecular mechanisms of cytokinesis, particularly the transition from contractile rings to midbody rings, and the roles of anillin, septins, and actomyosin dynamics in cell division using Drosophila as a model. His work has implications for cancer biology and drug development. Education: BSc (Manchester), PhD (University of Glasgow), Postdoctoral training (UCSF). Research Interests: Cytokinesis mechanisms, cytoskeletal coordination, cell division errors in cancer, and developmental variations in cytokinesis. His awards include the FRQS Senior Researcher Fellowship and multiple grants from CIHR and NSERC. He supervises graduate students and has mentored over a dozen researchers. His lab employs genetic tools and high-resolution microscopy to dissect cytokinesis machinery. He also contributes to teaching, including courses in molecular medicine and microscopy. Awards: Komen Postdoctoral Fellowship, Leukemia & Lymphoma Special Fellow, Cole Foundation Transition Award. Grants: Ongoing CIHR and NSERC funding (2022–2027) for cytokinesis research. Hickson collaborates with institutions like the CHU Sainte-Justine and leads projects on cytokinesis networks, septin assembly, and actomyosin coordination. His lab is part of the Azrieli Center and the Microscopy Imaging Platform.

• Cell Biology
• Molecular Biology
• Cancer Research
• +۴ مورد دیگر