معرفی
Dr. Shea Andrews is an Assistant Professor in the Department of Psychiatry at the University of California, San Francisco (UCSF) School of Medicine. As a genetic epidemiologist, Dr. Andrews leads the Andrews Lab which focuses on determining the causal pathways underlying Alzheimer's disease and related dementias through statistical genetic and genetic epidemiological approaches applied to large genetic and phenotypic datasets.
Dr. Andrews earned his PhD in Medical Sciences from the Australian National University in Canberra (2017), following a BSc (Hons) in Genetics (2012) and a BA in Journalism and Mass Communication and Political Science (2010), both from the University of Queensland in Brisbane.
Dr. Andrews' research centers on the role of genetic and environmental risk factors in Alzheimer's disease. His work specifically examines causal risk factors for Alzheimer's disease and related dementias using genetic correlations, polygenic risk scores, and Mendelian randomization. A significant portion of his research investigates the role of mitochondrial genomics in Alzheimer's disease pathogenesis and evaluates ancestry-specific effects of Alzheimer's genetic variants on disease endophenotypes. His interdisciplinary approach bridges genetics, epidemiology, and neuroscience to uncover the complex mechanisms underlying neurodegenerative conditions.
Analysis of Dr. Andrews' recent publications reveals a strong focus on causal inference methodologies in Alzheimer's research, particularly Mendelian randomization approaches. His work spans multiple dimensions of Alzheimer's disease including genetic risk factors, environmental influences, and cross-disease comparisons with other neurodegenerative conditions. A notable trend is the increasing attention to ancestry-specific effects in Alzheimer's research, reflecting a growing recognition of the importance of genetic diversity in understanding disease mechanisms.
- Ancestry-specific effects of APOE on AD endophenotypes and risk factors (Alzheimer's Association ABA-22-969581, 2022-2025) as Principal Investigator
- Elucidating the causal associations underlying Alzheimer's disease (NIH K99AG070109, 2021-2023) as Principal Investigator
- Assessing the causal role of mitochondria in Alzheimer's disease (Alzheimer's Association AARF-20-675804, 2020-2023) as Principal Investigator
The Andrews Lab operates at the intersection of genetics, epidemiology, and neuroscience, utilizing large-scale datasets and advanced statistical methods to uncover the causal pathways of Alzheimer's disease. The lab's work has significant implications for developing targeted interventions and personalized approaches to dementia prevention and treatment.
