Patrick Kehoe

Professor Patrick Kehoe is the Gestetner Professor of Translational Dementia Research at the University of Bristol's Bristol Medical School (THS) and Director of Research, Enterprise and Innovation at the Elizabeth Blackwell Institute. He holds a B.Sc. from Trinity College Dublin and a Ph.D. from Cardiff University, Wales. His work focuses on cerebrovascular hypertension, Alzheimer’s disease mechanisms, vascular cognitive impairment, and translational medicine. He leads studies on drug repurposing strategies targeting the renin-angiotensin system to mitigate dementia progression.

Key research interests include genetic epidemiology of dementias, polygenic risk stratification, and drug efficacy trials such as the RADAR trial evaluating losartan’s role in Alzheimer’s pathology. He collaborates with institutions like the European Alzheimer’s Disease Consortium and the UK Biobank to investigate environmental and genetic risk factors.

Recent articles emphasize Mendelian randomization analyses of antihypertensive drug repurposing, epigenetic biomarkers in Lewy body dementias, and cross-ancestry polygenic risk score applications. His work bridges basic science and clinical translation, addressing vascular contributions to neurodegeneration.

He advises on dementia policy and clinical trial methodologies, contributing to consensus guidelines for decentralized trials and pharmacoeconomic evaluations of emerging therapies. His translational focus spans drug discovery pipelines, biomarker validation, and precision medicine approaches for at-risk populations.