Shantu Amin

Shantu Amin is a Professor in the Department of Pharmacology at the Pennsylvania State University College of Medicine, located in Hershey, PA. His research focuses on mechanisms of chemical carcinogenesis, particularly the role of polycyclic aromatic hydrocarbons (PAHs) and their mutagenic effects. He investigates structure-activity relationships of carcinogenic compounds and strategies for chemoprevention.

Key areas include DNA adduct formation, environmental carcinogens like dibenzo[a,l]pyrene, and the interplay between microbial metabolites and host signaling pathways (e.g., Ah receptor activation). Recent work explores drug-tolerant persister cells in cancer therapy resistance and the development of novel therapeutic agents.

Amin collaborates widely, with contributions to studies on bile acid metabolism, miRNA delivery systems, and the gut-lung axis. His work bridges basic science with translational research, aiming to reduce cancer morbidity through targeted interventions.