معرفی
Shannon M. Buckley, PhD, is a Professor in the Department of Internal Medicine at the University of Utah School of Medicine, with adjunct appointments in Biochemistry and Oncological Sciences. Her lab investigates molecular mechanisms in hematopoiesis and lymphoma, focusing on ubiquitin E3 ligases and the ubiquitin proteasome system (UPS).
- Education:
- PhD, University of Minnesota
- Fellowship, New York University School of Medicine
- BA, University of St. Thomas, Minnesota
Dr. Buckley’s research explores how UPS components like FBOX proteins and UBR5 regulate hematopoietic stem cell (HSC) fate, differentiation, and malignant transformation in lymphomas and leukemias. Her work emphasizes the translational potential of UPS-targeted therapies for cancer and stem cell applications.
Recent publications highlight her team’s discoveries in ubiquitin-mediated regulation across diseases like mantle cell lymphoma (MCL), acute myeloid leukemia (AML), and developmental disorders. Key findings include:
- FBXO9’s role in pluripotency
- UBR5 mutations in B-cell maturation
- FBXO21 in AML progression
- UPS as a druggable target for cancer therapy
Dr. Buckley was recently appointed Co-Leader of the Cell Response and Regulation Program at Huntsman Cancer Institute, where she integrates genomic, proteomic, and translational approaches to advance hematologic malignancy research.
