Shankar Pandey

Shankar Pandey is a Research Fellow in the Department of Internal Medicine at Yale School of Medicine, affiliated with the Schwartz Lab. His research focuses on biophysical and molecular mechanisms of DNA structures, including G-quadruplexes and i-motif, under nanoconfinement conditions. He employs advanced techniques such as single-molecule force spectroscopy, DNA origami engineering, and optical tweezers to investigate molecular interactions and mechanochemical properties.

Key research interests include understanding how nanoconfinement affects DNA stability and conformation, designing mechano-pharmaceutical screening platforms, and exploring cooperative binding phenomena in molecular systems. His work bridges biophysics, nanotechnology, and molecular biology to address challenges in drug design and structural analysis.

Pandey’s recent publications highlight advancements in DNA origami-based reactors, allosteric binding in G-quadruplexes, and intermolecular force measurements in host-guest systems. His contributions emphasize interdisciplinary approaches to unravel fundamental biological and chemical processes at the nanoscale.

Lab affiliation: Schwartz Lab, Yale School of Medicine.