معرفی
Scott Prosser is a Professor at the University of Toronto Mississauga, Department of Chemistry. His research focuses on dynamics of complex biological processes, including protein folding, amyloidosis, enzyme dynamics, and GPCR functional mechanisms. He uses advanced NMR techniques like 19F and 13C,1H NMR to study molecular environments and conformational states. Recent work emphasizes high-yield protein expression in yeast for studies of conformational equilibria and activation mechanisms.
Key research areas include: 1) Protein misfolding and aggregation, 2) GPCR-ligand interactions, 3) Enzyme functional dynamics, and 4) Direct molecular imaging via MRI. His lab develops novel fluorine-based NMR tags and explores their applications in drug discovery and biophysical assays.
Publications highlight advances in NMR methodology, GPCR signaling pathways, and allosteric regulation mechanisms. Notable contributions include elucidating the role of oxygen in relaxation enhancement and characterizing conformational landscapes of receptors like the adenosine A2A receptor.
No academic awards or grants are explicitly mentioned in the provided texts. His advising activities are not detailed here, but his research group likely engages in collaborative projects involving enzyme complexes and membrane proteins.
