معرفی
Mikael Akke is a Professor in Biophysical Chemistry and Assistant Head of the Department of Chemistry at Lund University. His research focuses on understanding protein dynamics and their role in biological functions using nuclear magnetic resonance (NMR) spectroscopy. He leads a research group developing novel NMR methods to study protein dynamics across multiple time scales, with applications in drug design and understanding protein misfolding.
Research Interests:
- Protein dynamics and conformational entropy in ligand binding and allostery
- Enzyme catalysis and protein misfolding/aggregation mechanisms
- NMR spectroscopy and molecular dynamics simulations
- Development of new NMR methodologies for studying transient protein states
Recent Projects:
- Decoding Dynamics and Energetics of Allosteric Signaling (Knut and Alice Wallenberg Foundation, 2023–2028)
- DynaPLIX: Dynamics of Protein-Ligand Interactions (European Commission, 2023–2029)
- Protein Dynamics and Conformational Disorder in Molecular Recognition (Swedish Research Council, 2022–2026)
Awards and Honors:
- Member of the Royal Swedish Academy of Sciences (2013)
- Member of the Royal Physiographic Society in Lund (2012)
- The Göran Gustafsson Prize in Chemistry (2007)
- Professeur Invité, École Normale Supérieure, Paris (2005)
- The Arrhenius Medal (2004)
Grants and Collaborations:
Active in securing major grants, including leadership roles in interdisciplinary projects such as MoReLife: Molecular Recognition in Life (2010–2019). Collaborates internationally, with notable partnerships in structural biology and drug discovery.
Labs and Teams:
Leads a research group at Lund University’s Biophysical Chemistry division, focusing on NMR-based studies of protein dynamics and their functional implications.
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