Scot Wolfe

Scot Wolfe is a Professor at UMass Chan Medical School, affiliated with the Department of Molecular, Cell and Cancer Biology. He holds multiple academic roles across institutions including T.H. Chan School of Medicine and Morningside Graduate School of Biomedical Sciences. His research focuses on engineering CRISPR-Cas9 systems for gene therapy, targeting diseases like sickle cell anemia and muscular dystrophy. Wolfe's work emphasizes precision genome editing, delivery systems, and applications in hematopoietic stem cell therapy. Collaborations include projects on HIV latency, zebrafish genomics, and Neurofibromin gene therapy. His lab (wolfe-lab.org) innovates tools like Cas9-ZFP fusions and delivery methods for clinical applications.

Education: B.S. from Caltech (1990), Ph.D. from Harvard (1996). Postdoc at MIT. Research spans protein-DNA recognition, zinc finger engineering, and transcription factor specificity. Over 150+ publications focus on gene editing mechanisms and therapeutic applications. Active in the NIH Somatic Cell Genome Editing program.

Key projects include enhancing CRISPR specificity, ex vivo editing of HSPCs, and combating genetic disorders via base editing and prime editing. His team develops therapies for beta-hemoglobinopathies, limb-girdle muscular dystrophy, and Hermansky-Pudlak Syndrome. Ongoing work explores HIV cure strategies through proviral inactivation.