معرفی
Satish Nadig serves as the Edward G. Elcock Professor of Surgical Research, Chief of Organ Transplantation in the Department of Surgery, and Director of the Comprehensive Transplant Center at Northwestern University.
His educational credentials include:
- MD (2003) from the Medical University of South Carolina
- PhD (2008) from the University of Oxford, UK
Dr. Nadig's research centers on mitigating ischemia-reperfusion injury (IRI) in organ transplantation through innovative nanotherapeutic strategies. His laboratory developed the Targeted Rapamycin Micelle (TRaM) nanoparticle system that specifically targets graft endothelial cells to reduce oxidative stress, mitochondrial dysfunction, and pro-inflammatory cytokine production. This approach demonstrates significant downregulation of memory T-cell responses critical in acute rejection while sparing standard induction immunosuppression pathways. His work bridges nanomedicine, transplant immunology, and vascular biology to improve long-term allograft survival.
He directs the Comprehensive Transplant Immunobiology Laboratory where his team investigates how early post-transplant injuries initiate chronic dysfunction cascades, with current focus on endothelial cell targeting via cyclic peptide-decorated nanoformulations delivered through preservation solutions.
