معرفی
Sarah Thompson is an Associate Research Scientist in Surgical Oncology at the Yale School of Medicine, Yale University. Her research focuses on understanding mechanisms of chromosomal instability and aneuploidy in cancer cells, with particular emphasis on therapeutic targets and molecular pathways. She investigates how cellular stress responses and kinetochore-microtubule dynamics influence aneuploidy tolerance and cancer progression.
Her work spans from basic cellular mechanisms to translational research, including developing kinase inhibitors like GSK923295 to study aneuploidy induction. Key contributions include uncovering the role of p38α stress kinase and p53-dependent mechanisms in suppressing aneuploidy-driven cancer growth.
Publications highlight interdisciplinary approaches combining cancer biology, genetics, and drug development. Her articles explore topics such as aneuploidy dependency in tumors, mitotic catastrophe as therapeutic targets, and the interplay between chromosome segregation errors and cancer progression.
Thompson collaborates across departments within the Yale School of Medicine, contributing to surgical oncology research while maintaining strong ties to the broader cancer biology community. Her research aims to bridge mechanistic insights with clinical applications for improved cancer therapies.
