Sarah Hedtrich

Dr. Sarah Hedtrich is an Associate Professor at the School of Biomedical Engineering (University of British Columbia), with research affiliations to the Faculty of Medicine and Faculty of Pharmaceutical Sciences. Her work bridges Nanotechnology, Bioengineering, and Gene Therapy, focusing on Human Epithelia and Next-Generation Therapies for inflammatory and genetic diseases.

• Key research themes: Human Disease Models, Organ-on-Chip Technology, Nanomedicine, Tissue Regeneration, Anti-Fibrotic Strategies

Dr. Hedtrich’s lab develops complex human-based organ- and organ-on-chip (OoC) models to unravel pathological mechanisms and test novel therapies. These models address critical gaps in translational biomedical research, particularly in skin, lung, and intestinal diseases. Her team explores gene therapy, lipid nanoparticle (LNP) delivery systems, and sublingual/nasal protein delivery, emphasizing precision and safety.

Recent publications highlight advancements in TSLP inhibition for atopic diseases, LNP surface engineering, and mucus interactions in cystic fibrosis. Her work spans drug development, CRISPR gene editing, and biocompatibility studies, reflecting interdisciplinary collaborations with clinicians and engineers.