Alexandra S. Piotrowski-Daspit

Alexandra S. Piotrowski-Daspit is an Assistant Professor in the Department of Biomedical Engineering at the University of Michigan. Her work focuses on developing polymeric nanoparticles for gene and drug delivery systems, particularly targeting genetic disorders like cystic fibrosis and congenital diaphragmatic hernia.

Educational Background

• S.B. in Chemical-Biological Engineering and Biology, Massachusetts Institute of Technology (MIT)
• Master’s and Ph.D. in Chemical and Biological Engineering, Princeton University
• Postdoctoral Fellowship in Biomedical Engineering, Yale University

Research Interests

Her research integrates nanotechnology and molecular biology to create advanced delivery systems for nucleic acids. Key areas include in utero gene editing, mRNA-based therapies for respiratory diseases, and optimizing nanoparticle surface chemistry for targeted delivery. Her lab, the DYnamic NAnoMEDicines Lab, explores applications in cystic fibrosis correction, fetal therapy, and vaccine development.

Article Trends

Recent work emphasizes in vivo and in vitro validation of polymeric nanoparticles for delivering mRNA and gene-editing tools. Studies highlight advancements in targeting fetal lungs, correcting CFTR mutations, and enhancing nanoparticle biocompatibility.

Lab & Collaborations

Her DYnamic NAnoMEDicines Lab develops translational nanomedicines for genetic disorders. Collaborations span materials science, immunology, and pediatric medicine to bridge preclinical and clinical applications.