معرفی
Sangwon Lee is an Assistant Professor of Pharmacology at Yale University’s Yale School of Medicine. He holds primary appointments in Pharmacology and affiliations with the Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) program, Janeway Society, and Molecular Medicine department. His academic journey includes a PhD in Chemistry and Biochemistry from the University of California, San Diego (2007), and earlier degrees from Konkuk University (MS 1998, BS 1996).
Dr. Lee’s research focuses on structural biology and molecular mechanisms of FGF signaling pathways, particularly the role of β-Klotho and α-Klotho co-receptors in endocrine regulation. He designs novel protein-based inhibitors targeting oncogenic receptors and explores therapeutic applications of FGF pathway modulation. His work bridges computational protein engineering, cryo-EM structural analysis, and translational medicine.
Key research trends include isoform-specific FGFR inhibition, structural oncology of KIT mutants, and bivalent interactions in FGF ligand systems. His lab collaborates extensively on projects involving designed oligomeric assemblies for vascular differentiation and drug delivery. Current efforts emphasize translating structural insights into therapeutic strategies for cancer and metabolic disorders.
Dr. Lee’s academic contributions include leadership in the Yale Combined Program in the Biological and Biomedical Sciences (BBS), mentoring trainees, and serving on committees for academic promotion and interdisciplinary research. His laboratory is located at Sterling Hall of Medicine, Room 395F.
