معرفی
Sandra Sobočanec is an Assistant Professor and Senior Research Associate at the Ruđer Bošković Institute's Division of Molecular Medicine, Laboratory for Metabolism and Aging in Zagreb, Croatia. Her research focuses on molecular mechanisms of aging, metabolism, and oxidative stress with particular emphasis on sex-specific responses.
Her primary research interests include Sirtuin 3 (SIRT3) biology, sex-dimorphic metabolic responses, mitochondrial function, and oxidative stress in aging and disease. Current work investigates SIRT3's role in obesity-related diseases through the HrZZ IP-2020-10-4806 project "Obese Sirt". Her studies reveal fundamental sex differences in metabolic regulation, particularly in hepatic and neuronal systems under high-fat diet conditions and oxidative stress.
Analysis of her 15 most recent publications shows a consistent focus on SIRT3-mediated redox signaling across multiple model systems including mouse embryonic fibroblasts, breast cancer cells (MCF-7, MDA-MB-231), and in vivo murine models. Key trends include sex-specific gene expression patterns, interactions with estrogen signaling, and therapeutic potential of SIRT3 modulation in metabolic disorders and cancer.
Dr. Sobočanec has supervised graduate research including Grazia Davidović's diploma thesis on SIRT3's tumor-suppressive effects. She collaborates extensively within the Ruđer Bošković Institute and with international partners on projects involving hyperoxia therapy, mitochondrial metabolism, and cancer biology.
