Sami El Hilali

Sami El Hilali is a Researcher affiliated with the Guse Lab at Ludwig-Maximilians-Universität München. His work focuses on genomic stability, particularly mechanisms governing DNA replication stress, common fragile sites, and their implications in cancer and neurodevelopmental disorders. He contributes to cutting-edge research on genome assembly in extremophile organisms and develops bioinformatics tools for genomic visualization.

Research interests include:

• DNA replication dynamics and checkpoint regulation
• Genome instability in fragile X syndrome
• Transcription-replication interactions
• Functional genomics of extreme environments

Key contributions bridge molecular mechanisms (e.g., ATR/DDK signaling) with large-scale genomic analyses, employing innovative tools like macrosyntR for Oxford Grid visualization. Current projects explore how replication stress impacts chromosomal architecture and disease pathogenesis.

His lab affiliations emphasize collaboration on multi-organism studies from model systems to hydrothermal vent species, revealing fundamental principles of genome organization under stress conditions.