Sam Mesiano

Sam Mesiano is a William H. Weir, MD Professor of Reproductive Biology at Case Western Reserve University School of Medicine. He holds dual appointments in Obstetrics and Gynecology at University Hospitals Cleveland Medical Center, serving as Vice Chair for Research and Director of the Research Division. His research focuses on hormonal mechanisms controlling parturition timing, particularly progesterone signaling pathways and inflammatory triggers of preterm labor.

• Education: PhD in Physiology (Monash University, Australia), Postdoctoral Fellowships in Reproductive and Pediatric Endocrinology (UCSF)
• Labs/Teams: Mesiano Lab studies endocrine-immune interactions in pregnancy, with translational focus on preventing preterm birth

Key research themes include progesterone withdrawal mechanisms, cytokine effects on myometrial cells, and novel therapies targeting parturition pathways. Over 79 peer-reviewed publications span 2002–2024, emphasizing progesterone biology and clinical obstetrics.