معرفی
Sam Lai, PhD is a Professor at the UNC School of Pharmacy and a member of the UNC Lineberger Comprehensive Cancer Center. His research spans immunology, nanotechnology, and bioengineering, with a focus on mucosal barriers and therapeutic delivery systems.
- Departments: Pharmacoengineering & Molecular Pharmaceutics, Immunology
- Area of Interest: Molecular Therapeutics
Research Highlights
The Lai Lab investigates:
- Antibody engineering for mucosal applications (respiratory infections, contraception)
- Overcoming anti-drug immune responses against nanomaterials
- Bispecific antibodies for tumor microenvironment modulation
- Viral vector engineering for in vivo immune cell therapy
- Phage-based microbiome modulation
- Computational modeling of biological barriers
Scientific Impact
Key advancements include:
- First demonstration of mucin-Fc interactions for pathogen trapping
- Clinical translation of anti-sperm antibodies for contraception
- Developing FDA-approved drugs and founding biotech startups (Inhalon Biopharma, Mucommune, Polyon)
Scientific Awards
Recipient of:
- Packard Fellowship in Science and Engineering (2013)
- NSF CAREER Award (2012)
- IBM Junior Faculty Development Award (2013)
- Multiple early-career and graduate/postdoctoral fellowships
Publications & Clinical Applications
His work on muco-trapping antibodies and PEG-immunogenicity has led to clinical trials (2023-2026) and patents in mucosal drug delivery. Articles span computational modeling, nanotechnology, and immunotherapies for HIV, Ebola, and cancer.
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