Sajid A Khan

Sajid A. Khan, MD is an Associate Professor of Surgery (Oncology) at Yale School of Medicine, where he serves as Chief of Hepato-Pancreato-Biliary & Mixed Tumors and Co-Director of Team Science at Yale Center for Clinical Investigation (YCCI). Board-certified in Complex General Surgical Oncology and General Surgery, he specializes in gastrointestinal cancers including liver, pancreas, and colorectal tumors, with a research focus on metabolomics and transcriptomics to understand metastasis mechanisms and develop biomarkers.

• MD from SUNY Upstate Medical University (2003)
• Residency at Oregon Health & Science University (2009) and Albert Einstein College of Medicine/Montefiore (2005)
• Research Fellowship at Memorial Sloan-Kettering Cancer Center (2007) and Clinical/Research Fellowship at University of Chicago Medical Center (2013)
• Current leadership roles in SSAT Research Committee and editorial boards

His Khan Lab at Yale conducts translational research on liver metastasis, pancreatic cancer biomarkers, and genomic drivers of GI cancers, funded by NIH R01/R21 grants. Recent studies examine sex-specific metabolic responses in colorectal cancer and tumor microbiome interactions. He has published >100 papers and received multiple Castle Connolly Top Doctor awards (2023-2025).

• Principal Investigator for SWOG national chemoprevention trial
• Co-Leader of Advanced Hepatobiliary Disease Program at Yale Cancer Center
• Advocate for multidisciplinary patient care using minimally invasive techniques