معرفی
Ryan B. Jensen is an Associate Professor of Therapeutic Radiology and Pathology at Yale School of Medicine. His research is primarily focused on DNA repair mechanisms, with a special emphasis on the BRCA2 protein and homologous recombination pathways. He directs the Jensen Lab, which is affiliated with multiple Yale research centers including the Yale Cancer Center, Women's Health Research at Yale, and the Yale Combined Program in the Biological and Biomedical Sciences.
- Yale School of Medicine - Therapeutic Radiology Department (Primary Appointment)
- Yale School of Medicine - Pathology Department (Secondary Appointment)
- DNA Damage and Genome Integrity Research Group
- Molecular Medicine, Pharmacology, and Physiology Program
- WHRY Pilot Project Program Investigators
- Yale Ventures
Dr. Jensen's research centers on understanding the molecular mechanisms of DNA double-strand break repair, particularly the role of BRCA2 in homologous recombination. His lab employs a multi-disciplinary approach combining biochemistry, genetics, cell biology, structural biology, and proteomics to investigate how BRCA2 and other proteins involved in homologous recombination signal and catalyze DNA repair reactions. A major focus is on understanding the functional consequences of BRCA2 interactions with proteins like PALB2, BRCA1, FANCD2, EMSY, DMC1, and DSS1, and how disruptions in these pathways lead to cancer development.
Analysis of Dr. Jensen's recent publications (2019-2025) reveals a consistent research trajectory focused on BRCA2 function, DNA repair mechanisms, and cancer biology. His work spans fundamental biochemical characterization of DNA repair proteins, development of novel methodologies for studying replication dynamics, and translational research connecting DNA repair defects to cancer therapeutics. A notable trend is the increasing focus on clinical applications, particularly regarding BRCA2 variants of uncertain significance and their implications for personalized cancer treatment.
Dr. Jensen has collaborated extensively with researchers across Yale, with frequent co-authors including Peter M. Glazer, Ranjit S. Bindra, Adam Krysztofiak, Faye Rogers, Fengshan Liang, and Joann Sweasy. His work has appeared in high-impact journals including Nature, Molecular Cell, and ELife.
As a mentor, Dr. Jensen oversees graduate and undergraduate students in his lab, including Jennifer Garbarino and Joshua Matthew. His research has been supported by various funding mechanisms that enable the multi-disciplinary approach to studying DNA repair mechanisms and their implications for cancer biology and treatment.
Dr. Jensen leads the Jensen Lab, which maintains a strong focus on understanding the molecular basis of DNA repair and its connection to cancer development. The lab has developed specialized techniques for purifying and characterizing large DNA repair proteins like BRCA2, which has enabled groundbreaking biochemical studies of these critical cancer-related proteins.
