Gemma Moore

Gemma Moore is an Associate Research Scientist in the Department of Therapeutic Radiology at the Yale School of Medicine, Yale University. Her research focuses on DNA repair mechanisms in cancer biology, particularly BRCA1/2 mutations and their implications for cancer treatment. She investigates the role of proteins like BRCA2, RAD51, and PARP1 in DNA repair pathways and explores mechanisms of resistance to PARP inhibitors. Her work includes studying reversion mutations in BRCA2 that restore protein functionality and contribute to therapeutic resistance.

Moore holds a PhD in Biotechnology from Dublin City University (2017) and a BSc (Honors) in Biotechnology from the same institution (2011). She collaborates with researchers such as Ryan B. Jensen and Joseph Paul Eder, contributing to peer-reviewed publications in journals like eLife and STAR Protocols.

She is affiliated with the Jensen Lab, where her research integrates molecular biology techniques, including DNA fiber combing protocols for replication fork dynamics analysis. Her academic contributions span oncology, genetics, and pharmacology, with a focus on translational applications in cancer therapy.