معرفی
Rupal C Mehta, MD, MSCI serves as Assistant Professor of Medicine in the Division of Nephrology and Hypertension at Northwestern University Feinberg School of Medicine. She holds core membership in the Center for Translational Metabolism and Health (Institute for Public Health and Medicine) and affiliates with the Feinberg Cardiovascular and Renal Research Institute and Northwestern University Clinical and Translational Sciences Institute.
Her educational pathway includes:
- MD from University of Illinois, Chicago (2008)
- MSCI from Northwestern University Graduate School (2021)
- Internal Medicine Internship at Case Western Reserve University Hospital (2009)
- Internal Medicine Residency at Case Western Reserve University (2011)
- Chief Medical Residency at Case Western Reserve University Hospital (2012)
- Nephrology Fellowship at Northwestern University McGaw Medical Center (2014)
- Postdoctoral Nephrology Fellowship at Northwestern University (2016)
Dr. Mehta's research program centers on cardiovascular complications in chronic kidney disease (CKD), specifically targeting diagnostics and therapeutics for heart failure. Her methodology integrates population-based cohort studies with interventional patient-oriented research to identify mechanistic pathways and therapeutic targets. Key investigative domains include:
- Pathogenesis of heart failure with preserved ejection fraction (HFpEF) in CKD
- Genetic and proteomic biomarkers for cardiovascular risk stratification
- Cardiac mechanics alterations in mineral metabolism disorders
- Coronary artery calcification progression in renal impairment
Recent publications (2024-2025) demonstrate a cohesive research trajectory leveraging large cohorts like CRIC and Cardiovascular Health Study. Current work emphasizes molecular mechanisms linking CKD to heart failure through genetic variants (ICAM1), fibroblast growth factor 23 dynamics, coronary calcification imaging, and proteomic risk signatures—establishing translational bridges between renal and cardiovascular pathophysiology.
Her accolades include:
- Samuel A. Levine Early Career Investigator Award Finalist (AHA, 2020)
- Three consecutive Feinberg Teaching Pins (2018-2020)
- Northwestern University Excellence in Teaching Award (2013)
- William A Bernbaum Intern of the Year (Case Western, 2010)
Dr. Mehta leads active clinical trials including the Pathogenesis of HFpEF in CKD study (IRB STU00210997), examining early cardiac dysfunction in CKD patients. She contributes to scientific advancement through editorial roles at Journal of Cardiac Failure and committee leadership in National Kidney Foundation and American Heart Association initiatives.
As integral to Northwestern's Center for Translational Metabolism and Health and Center for Kidney Research and Therapeutics, she collaborates with multidisciplinary teams spanning nephrology, cardiology, and metabolomics to address complex cardiorenal syndromes through bench-to-bedside approaches.
