معرفی
Dr. Roberta Zappasodi is an Assistant Professor at Weill Cornell Medicine's Graduate School of Medical Sciences, affiliated with the Hematology in Medicine department. Her research focuses on tumor microenvironmental cues that limit immune responses and immunotherapy efficacy.
- Education: Ph.D. in Tumor Immunology & Immunotherapy from Open University (UK) at the National Cancer Institute of Milan; M.Sc. in Medical Biotechnology from University of Bologna (Italy).
The Zappasodi lab investigates how tumor metabolic adaptations deplete nutrients critical for immune cell function, impairing anti-tumor responses. Key projects include modulating tumor metabolism to enhance immunosurveillance, harnessing CD4+ T cells in cancer therapy, and studying immune evasion mechanisms in B-cell lymphomas. Her work bridges mouse models and clinical studies to understand tumor-immune interactions.
Recent publications highlight her expertise in immunometabolism, regulatory T cell dynamics, and metabolic targeting strategies to overcome immunotherapy resistance. Articles span topics like LDH inhibition, EZH2 modulation, and metabolic-angiogenesis-immune axis interactions.
- Scientific Awards:
- Breast Cancer Alliance Young Investigator Grant (2023)
- Leukemia & Lymphoma Society Translational Research Program Award (2021)
- AACR Women in Cancer Research Scholar Award (2020)
- Parker Institute for Cancer Immunotherapy Bridge Scholar Award (2019)
- Popular Mechanics Breakthrough Award (2017)
- Parker Institute for Cancer Immunotherapy Scholar Award (2016)
- SITC Presidential Award (2016)
Her research has been supported by grants from the Parker Institute, Breast Cancer Alliance, and AACR, with a focus on translating mechanistic insights into novel therapeutic combinations.
The lab collaborates with Memorial Sloan Kettering Cancer Center and participates in tri-institutional programs, emphasizing interdisciplinary approaches to cancer immunology.
