معرفی
Dr. Richard Kibbey is an Ensign Professor of Medicine (Endocrinology and Metabolism) and Professor of Molecular and Cellular Physiology at Yale School of Medicine. He leads the Kibbey Lab, which focuses on mitochondrial metabolism, metabolic flux analysis, and the pathophysiology of diabetes. His research integrates clinical insights with advanced biochemical techniques, particularly using 13C mass spectrometry and the MIMOSA method.
- Department: Internal Medicine (Endocrinology) and Cellular & Molecular Physiology
- Administrative Roles: Faculty Director, Core in Chemical Metabolism; Associate Director, Yale Program for Translational Biomedicine
- Education: MD/PhD from University of Texas Southwestern; Residency and Fellowship at Yale
His research interests center on mitochondrial metabolism, insulin secretion, metabolic equilibrioception, and metabolic diseases such as Type 2 Diabetes. He discovered mitochondrial GTP (mtGTP) as a key metabolic signal in beta-cells and hepatocytes. His lab developed the MIMOSA platform to resolve complex metabolic fluxes in vivo.
Recent publications highlight work on pyruvate kinase, beta-cell bioenergetics, mitochondrial respiration, and cancer metabolism. His studies span diabetes, obesity, liver regeneration, and endothelial metabolism, showing a strong trend toward translational applications of metabolic insights.
Scientific Awards and Honors:
- Ralph Hart Ensign Chair in Medicine (Nominee)
- Visiting Professor, Vanderbilt University (2016, 2014)
- Visiting Professor, German Diabetes Center (2013)
Dr. Kibbey actively mentors students and postdoctoral fellows and collaborates with leading scientists like Gerald Shulman. He holds multiple NIH grants and leads core facilities in chemical metabolism. His lab is part of the Yale Center for Molecular and Systems Metabolism and the Diabetes Research Center.