معرفی
Professor Richard Bayliss is a leading academic in molecular medicine and structural biology at the University of Leeds, where he holds the position of Professor of Molecular Medicine in the School of Molecular and Cellular Biology. He is also a key member of the Astbury Centre for Structural Molecular Biology, contributing to interdisciplinary research in structural and cellular biology.
- University: University of Leeds
- School: School of Molecular and Cellular Biology
- Research Centre: Astbury Centre for Structural Molecular Biology
- Academic Rank: Professor
His research focuses on the structural and functional mechanisms of proteins involved in cancer, particularly protein kinases, transcription factors like Myc, and mitotic spindle dynamics. He employs structural, chemical, computational, and cell biology methods to understand disease mechanisms and develop precision therapeutics.
The recent publications highlight a consistent focus on kinase regulation, protein-protein interactions, and targeted drug design in cancer. Key themes include the structural basis of oncogenic fusions like EML4-ALK, mechanisms of kinase activation (e.g., NEK9/NEK7, IRE1), and targeting adaptive resistance in lung cancer. The work spans from atomic-level structural insights to translational applications in patient stratification and therapy.
His scientific awards and recognitions include the Frank May Prize, a Royal Society Research Fellowship, and an EMBO Long Term Fellowship, underscoring his contributions to molecular and structural biology.
- Frank May Prize
- Royal Society Research Fellowship
- EMBO Long Term Fellowship
Professor Bayliss has mentored numerous researchers and welcomes PhD students into his lab. His research has been supported by major funding bodies including the BBSRC, MRC, and Cancer Research UK. He has led significant projects on dynamic protein interactions, cancer signalling pathways, and structure-based drug discovery. He previously held positions at the Institute of Cancer Research and the University of Leicester before joining Leeds in 2016. He served as Head of School from 2018 to 2019, demonstrating leadership in academic administration.
The Bayliss Lab operates within the Astbury Biostructure Laboratories, utilizing state-of-the-art cryo-EM and structural biology facilities. The team collaborates widely across the UK and internationally, particularly in Seoul, to bridge structural insights with clinical oncology.
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