Renzo Mancuso

Renzo Mancuso is a Professor at the University of Antwerp, leading the Mancuso Lab at the VIB-UAntwerp Center for Molecular Neurology. His research focuses on the molecular mechanisms of neuroinflammation in neurodegenerative disorders, particularly Alzheimer's disease and Frontotemporal dementia.

• Group Leader, VIB-UAntwerp Center for Molecular Neurology
• Specializes in microglial biology and neuroinflammatory networks

Research Interests include:

• Microglia-driven neuroinflammatory mechanisms
• Genetic contributions to brain disease
• Humanized mouse models for neurodegeneration
• Transcriptomic and epigenomic alterations in disease
• Therapeutic targeting of inflammatory pathways
• Stem cell-derived microglial transplantation

Key Trends in Publications (2016–2025) demonstrate expertise in:

• Microglial heterogeneity across disease models
• Translational applications of antisense oligonucleotides
• Comparative proteomic analysis of microglial systems
• Role of APOE isoforms in neuroinflammation
• Immune homeostasis disruption in neurodegeneration
• Maternal obesity impacts on metabolic disorders

Advising includes mentoring 9 PhD students and collaborating with postdoctoral researchers like Rita Cacace and Laura Fumagalli. The lab employs 4 technicians and 1 bioinformatician, with alumni such as Joke Verbist and Nele Goosens.

Our Team includes: Heidi Denton (Lab Manager), Giacomo Muscarnera (Technician), Tim Meese (Bioinformatician), and Birgit Voeten (Technician).