معرفی
Joke Terryn serves as a Clinical Lecturer at KU Leuven's Faculty of Medicine, affiliated with the Laboratory of Neurobiology (VIB-KU Leuven) located at ON5 Herestraat 49 in Leuven. Her research integrates clinical neurology with advanced stem cell technologies to investigate neurodegenerative mechanisms.
Her research focuses on neurodegeneration, particularly frontotemporal dementia linked to progranulin (GRN) mutations, movement disorders including chorea and CANVAS syndrome, and tauopathies. She employs patient-derived induced pluripotent stem cells to model disease mechanisms and develop therapeutic strategies, with emphasis on gene expression modulation and cellular phenotypes.
Analysis of her 10 most recent publications (2016-2024) reveals consistent focus on neurodegenerative disease modeling using stem cell platforms, with growing emphasis on genetic mechanisms (NKX2-1, RFC1, GRN) and therapeutic interventions. Her work bridges molecular neuroscience, clinical neurology, and regenerative medicine through collaborative projects across international consortia.
As co-promoter of the active project Multidimensional translational research to improve the diagnostic work-up of adult acquired spinal cord injuries secondary to degenerative changes of the cervical spine (2021-2025), she contributes to translational neuroscience initiatives. Her teaching portfolio includes advanced courses in neurobiology of disease and neurotechnology at KU Leuven.
Based at the VIB-KU Leuven Laboratory of Neurobiology, she operates within a multidisciplinary environment that combines molecular neuroscience, clinical neurology, and stem cell engineering to address fundamental mechanisms of neurodegeneration and develop novel diagnostic and therapeutic approaches.
