Raymond F Regan

Raymond F. Regan is a Professor in the Department of Emergency Medicine at Thomas Jefferson University, focusing on the molecular mechanisms of intracerebral hemorrhage (ICH) with limited treatment options. His research investigates how hemoglobin-derived toxins cause neuronal death after stroke, utilizing both cell culture and in vivo mouse models to identify novel therapeutic pathways.

Dr. Regan's primary research centers on hemorrhagic stroke pathology, specifically examining oxidative injury from hemoglobin breakdown products like iron. His laboratory employs primary neuron/astrocyte cultures and stereotactic ICH models to study heme oxygenase pathways, hemopexin-haptoglobin interactions, and neuroprotective strategies targeting iron chelation and oxidative stress mitigation.

• Key Techniques: Immunoblotting, fluorescence imaging, protein/lipid oxidation assays, cell viability testing
• Therapeutic Focus: Hemopexin, deferoxamine, heme oxygenase-1 induction, and blood-brain barrier protection

The research team actively explores translational applications for ICH treatment, with current projects investigating systemic hemin therapy, curcumin-induced neuroprotection, and molecular mechanisms of neuronal vulnerability to hemoglobin toxicity.