معرفی
Ranjana Mitra, PhD, is an Associate Professor of Biomedical Sciences at the College of Medicine, Roseman University of Health Sciences. She specializes in cancer biology, particularly prostate cancer, with a focus on identifying therapeutic targets and understanding the role of CYP3A enzymes in androgen receptor signaling. Her research also explores fatty acid pathways in circulating tumor cells (CTCs) and health disparities in African American men with prostate cancer.
Educational Background:
- PhD in Molecular Biology & Biotechnology, Jawaharlal Nehru University, New Delhi
- MSc in Molecular Biology & Biotechnology, Govind Ballabh Pant University
- BSc in Chemistry, Botany & Zoology, Deen Dayal Upadhaya Gorakhpur University
Research Interests:
Dr. Mitra's work centers on:
- Modulation of androgen receptor signaling via CYP3A5
- Genetic markers linked to prostate cancer disparities
- Lipid signaling mechanisms in CTCs
- CYP3A4's role in estrogen receptor-positive breast cancer
Her lab employs advanced imaging techniques like coherent anti-Stokes Raman scattering (CARS) to detect lipid-rich CTCs and investigates how drug metabolism impacts cancer therapy efficacy.
Publications Overview:
Her articles highlight trends in:
- Targeting CYP3A enzymes to enhance androgen deprivation therapy
- Using lipid metabolism as a biomarker for metastasis
- Repurposing HIV protease inhibitors for cancer treatment
- Addressing genetic misclassification in cancer cell lines
These studies bridge basic science with clinical applications, emphasizing translational oncology.
Professional Affiliations:
- Member, American Association for Cancer Research (AACR)
- Reviewer for Cancers, Molecular Cancer Therapeutics, and PLOS ONE
Labs/Teams:
Her lab at Roseman University focuses on CYP3A enzyme regulation, CTC detection, and lipid signaling in cancer progression. Collaborative efforts include studies on genetic ancestry and drug metabolism interactions.
