معرفی
Ralph E. Kleiner is an Associate Professor of Chemistry at Princeton University, leading the Kleiner Lab. His research focuses on understanding RNA function and regulation through chemical biology approaches, specifically investigating RNA-binding proteins (RBPs), RNA modifications, and developing chemical tools for studying RNA synthesis, turnover, and structure. Key areas include post-transcriptional regulation, epitranscriptomics, and therapeutic targeting of RBP interactions.
Education and affiliations are not explicitly detailed in the provided text, but his lab is located in the Frick Laboratory. Research highlights include developing tools like metabolic labeling and RNA editing platforms to study RNA-protein interactions, as well as characterizing RNA-modifying enzymes.
Research Interests: The lab explores the role of RBPs in RNA lifecycle processes, the functional significance of RNA modifications (e.g., 5-formylcytosine, m6A), and the development of chemical methods for RNA imaging and structural probing. Recent advancements include SNIPER-seq for RNA structure analysis and methods for studying ribonucleoprotein granules.
Awards and Honors:
- 2023: ICBS Young Chemical Biologist Award
- 2023: Kavli Fellow
- 2019: NSF CAREER Award
- 2019: Sloan Research Fellowship
- 2017: Sidney Kimmel Foundation Scholar Award
Lab and Collaborations: The Kleiner Lab collaborates across disciplines, integrating chemistry and biology to address fundamental and translational questions. Recent projects include preprints on DUS enzymes and RNA structure probing, and mentoring graduate students such as Tyler Schwarz and Crystal (PhD graduates). The lab also emphasizes outreach and training through its website and educational initiatives.
