معرفی
Brian D. Gregory is a Professor of Biology at the University of Pennsylvania's School of Arts & Sciences. His research focuses on RNA modifications, computational biology, and plant genetics, particularly studying how RNA modifications regulate gene expression in plants and animals. He holds a Ph.D. from Harvard University (2005) and a B.S.A. from the University of Arizona (2000).
Research Interests:
- RNA epitranscriptomics (e.g., m6A, NAD+ caps)
- RNA secondary structure and protein interactions
- Genomic approaches to study plant stress responses
- Development of high-throughput sequencing tools like PIP-seq
Recent Work Highlights:
Recent studies include analyzing pathogen-induced RNA modifications' role in plant immunity (Plant Cell 2023), global RNA structure/protein interaction mapping, and epitranscriptomic dynamics in drought tolerance. His lab's work bridges computational methods with molecular genetics to uncover post-transcriptional regulatory mechanisms.
Lab & Collaborations:
The Gregory Lab uses Arabidopsis thaliana as a primary model organism but also explores animal systems. They collaborate with institutions like Cornell University and have developed protocols published in Current Protocols in Molecular Biology.
Teaching:
- BIOL 4231: Genome Sciences and Genomic Medicine
- BIOL 6010: Communication for Biologists
