معرفی
Rakesh Mukherjee is a postdoctoral research associate at the Principles of Biomolecular Systems group, Imperial College London. His research focuses on autonomous, enzyme-free molecular templating systems using DNA strands to enable sequence-specific catalytic assembly with minimal product inhibition.
- Imperial College London (Current: Postdoctoral Research Associate)
- EPFL (Postdoc: Cyclic Peptide Inhibitors)
- Ben-Gurion University (PhD: Peptide Replication Networks)
- Indian Institute of Technology Guwahati (MSc: Organic Chemistry)
Research Interests span DNA nanotechnology, molecular replication, and non-covalent/covalent bond engineering. Key work demonstrates:
- DNA-based catalytic dimerization with weak product inhibition through toehold/handhold displacement
- Scaling to trimerization and covalent bond formation using copper-catalyzed click chemistry
- Information propagation in non-biological contexts via sequence-specific templating
Applications include:
- Diagnostics and molecular biophysics through DNA strand displacement circuits
- Labelled oligomers for downstream tasks like selective binding and gel formation
- Combinatorial libraries of biologically functional molecules via DNA-templated synthesis
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