معرفی
Rajat Singh, MB, BS, MD is an Adjunct Professor at the University of California Los Angeles (UCLA), holding appointments in the Department of Medicine (Endocrinology) and the Department of Developmental & Molecular Biology. His research focuses on autophagy's role in metabolic regulation across physiology, obesity, and aging. Singh leads the Lab of Rajat Singh, investigating how autophagy modulates lipid metabolism, energy homeostasis, and neural mechanisms controlling feeding behavior. His work employs biochemical, immunohistochemical, and in vivo approaches in mouse models to study organ-specific autophagy effects. Key areas include understanding how autophagy failure contributes to metabolic aging and developing interventions to counteract metabolic decline through dietary strategies like time-restricted feeding. His lab also explores autophagy's interplay with circadian rhythms and mitochondrial dynamics in metabolic disorders.
Research Interests: Singh’s work spans autophagy mechanisms, lipophagy, metabolic aging, hypothalamic signaling, and the impact of dietary interventions. He investigates how autophagy regulates lipid storage mobilization in neurons and peripheral tissues, linking these processes to obesity, diabetes, and age-related metabolic dysfunction. Recent studies highlight autophagy’s role in circadian clock regulation and mitochondrial health, with implications for neurodegenerative diseases and cardiovascular health.
Labs/Teams: The Lab of Rajat Singh integrates interdisciplinary approaches to study metabolic and cellular biology, collaborating on projects involving autophagy’s role in energy balance, aging, and disease. Key collaborations include work on autophagy-circadian clock interactions and mitochondrial quality control in metabolic stress.
