معرفی
Amandine Chaix serves as Assistant Professor in the Department of Nutrition and Integrative Physiology at the University of Utah, where her research explores the intersection of dietary patterns, circadian biology, and metabolic health. Her work focuses on developing time-based nutritional interventions to combat obesity, cancer, and age-related decline.
Education:
- B.S. from Ecole Normale Supérieure de Cachan and Paris XI University
- M.S. from Ecole Normale Supérieure de Cachan ("Grande Ecole"), Paris, and University of Sciences of Luminy
- Ph.D. from Aix-Marseille II University and Marseille Cancer Institute
Dr. Chaix's research program investigates how time-restricted feeding (TRF) and ketogenic diets modulate circadian rhythms to influence metabolic health. Her laboratory employs murine models to study TRF's protective effects against obesity, atherosclerosis, and cancer progression, while examining mechanisms linking diet timing to gut microbiome dynamics, lipid metabolism, and neuronal health. Recent work demonstrates TRF's efficacy in reducing tumor growth in obese breast cancer models and improving mitochondrial function in skeletal muscle.
Analysis of her 2023-2025 publications reveals consistent focus on dietary timing interventions, with key themes including: 1) TRF as a countermeasure for metabolic syndrome independent of caloric restriction, 2) paradoxical effects of ketogenic diets on liver health and glucose metabolism, 3) malnutrition-cancer mortality relationships in clinical populations, and 4) circadian regulation of multi-organ systems during aging. Her work bridges basic circadian mechanisms with translational applications for cancer and neurodegenerative disorders.
The Chaix Lab operates within the University of Utah's Molecular Biology Program infrastructure, utilizing advanced metabolic phenotyping, molecular biology, and bioinformatics approaches to investigate diet-circadian interactions. Current projects examine ceramide metabolism in Alzheimer's models, semaglutide effects on muscle physiology, and evolutionary conservation of hibernation-related metabolic adaptations.
