معرفی
Rajat Rohatgi is a Professor of Biochemistry and Medicine (Oncology) at Stanford University, with affiliations at multiple interdisciplinary institutes including Bio-X, Cardiovascular Institute, Maternal & Child Health Research Institute, Stanford Cancer Institute, and Wu Tsai Neurosciences Institute. His research focuses on signal transduction mechanisms, particularly the Hedgehog and WNT pathways, lipid regulation of signaling, phase separation in cellular organization, and responses to osmotic stress.
Research Trends from his 15 most recent publications indicate:
- Elucidating cholesterol's role as a second messenger in Hedgehog signaling
- Discovering phase separation mechanisms in transcriptional regulation and nucleolar disruption
- Mapping lipid droplet-mediated drug activation pathways
- Characterizing membrane-tethered ubiquitination in developmental signaling
- Identifying novel small molecule regulators of signaling pathways
Scientific Awards include:
- NIH Director's New Innovator Award
- V Foundation Martin D. Abeloff Scholar
- March of Dimes Basil O'Connor Award
- Stand Up To Cancer Innovation Grant
- Co-founding member of American Society for Clinical Investigation
Rohatgi mentors doctoral students in Biochemistry and Cancer Biology PhD programs, with advisees including Katie DeLong, Rae Brown, and Claire Chiang. His laboratory employs CRISPR/Cas9 screens, protein biochemistry, chemical probes, advanced imaging, and structural biology collaborations to investigate fundamental signaling mechanisms with implications for cancer and developmental disorders.
