معرفی
Pengxiang Huang is an Assistant Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine and a CPRIT Scholar in Cancer Research. His research focuses on elucidating mechanisms of signal transduction in Hedgehog and Wnt pathways, with expertise in biochemistry, chemical biology, and structural biology techniques including X-ray crystallography and Cryo-EM. He earned a BS from Tsinghua University (2002) and a PhD from the University of Virginia (2009).
- Education: PhD, University of Virginia (2009); BS, Tsinghua University (2002)
His research interests integrate structural, biochemical, and cellular approaches to study lipid-dependent signaling pathways critical for development and cancer. Key contributions include identifying cholesterol as the endogenous activator of Smoothened (SMO) in Hedgehog signaling and determining the structural basis of SMO activation. Current work expands to Wnt pathway mechanisms.
His publications highlight interdisciplinary strategies, such as structural studies of Wnt morphogen secretion and Hedgehog-Patched1 signaling complexes. These studies bridge basic biology with translational goals to develop cancer therapies targeting these pathways.
- Awards: CPRIT Scholar in Cancer Research (2020-2025)
Dr. Huang’s lab is actively recruiting researchers to advance studies in signaling pathways and structural biology. Collaborations focus on applying multidisciplinary methods to understand and modulate developmental and oncogenic signaling networks.
