R. Stephanie S Huang

R. Stephanie S Huang is a Professor in the Department of Experimental and Clinical Pharmacology at the University of Minnesota, specializing in cancer genetics and computational pharmacology. Her research focuses on pharmacogenomics, non-coding RNAs, and computational approaches for precision oncology.

Research Focus

Professor Huang leads NIH-funded investigations into:

• Genetic mechanisms of sexual dimorphism in cancer therapy response
• AR signaling pathways in prostate cancer
• Lineage plasticity in treatment-resistant cancers
• Computational drug discovery pipelines
• Single-cell transcriptomic analysis of drug responses

Publication Trends

Recent work demonstrates strong emphasis on computational oncology approaches for prostate cancer, including therapeutic target identification (e.g., NAMPT), metabolic pathway analysis, and integration of single-cell with bulk RNAseq data. Publications frequently appear in high-impact journals including PNAS and Clinical Cancer Research.

Grant Leadership

Actively leads multiple NIH grants including:

• Dynamic Digital Tumors for Precision Oncology (PI, 2025)
• Genetic Mechanisms of Sexual Dimorphism in Cancer (PI, 2024-2026)
• Cancer Center Support Grant (Co-I, 2024-2029)
• AR Signaling in Prostate Cancer (Co-I, 2023-2028)

Collaboration Network

Extensive multi-institutional collaborations with researchers at University of California San Diego, University of Colorado, and NIH-funded consortia.