معرفی
Premysl Bercik is a Professor in the Department of Medicine at McMaster University's Faculty of Health Sciences. His research focuses on the interaction between gut microbiota and the host's nervous and immune systems, particularly in disorders like irritable bowel syndrome (IBS), celiac disease, and inflammatory bowel disease (IBD). He has led studies on dietary interventions, microbial metabolites (e.g., histamine, phospholipids), and their impact on visceral pain and behavioral changes using humanized and gnotobiotic mouse models.
- Institution: McMaster University
- School: Faculty of Health Sciences
- Department: Department of Medicine
- Academic Rank: Professor
Research Interests: Bercik's work explores the microbiota-gut-brain axis, emphasizing how gut bacteria influence chronic gastrointestinal disorders, mood, and immune responses. Key areas include gluten/wheat effects on IBS, tryptophan metabolism via the aryl hydrocarbon receptor, proteolytic microbiota in Crohn's disease, and stress-induced bacterial translocation. His studies often bridge microbiology, immunology, and neuroscience to uncover mechanisms linking gut health to systemic and psychological conditions.
Recent Research Trends: His 2025-2024 publications highlight microbial phospholipids (LPC/LPA) as pain triggers in IBS, TRPC5/LPAR1-3 signaling in visceral hypersensitivity, and microbiota-mediated CGRP regulation. He investigates dietary interventions (low-FODMAP, tryptophan supplementation) and microbial metabolites' role in schizophrenia, Crohn's disease, and post-infectious IBS. His team also examines how rodent diet variability affects experimental reproducibility in microbiome research.
Collaborations: Bercik collaborates with institutions like Queen's University and leverages McMaster Experts for scholarly activity. His work spans clinical trials (e.g., gluten-free diet efficacy), mechanistic studies on receptors like PAR2 and AHR, and translational models of stress and dysbiosis.
