معرفی
Prateek Kumar serves as an Associate Research Scientist in the Department of Neurology at Yale School of Medicine, where he is a core member of the Rangaraju Lab. His work bridges advanced proteomic methodologies with neurological disease mechanisms, focusing on translational applications for neurodegenerative disorders and stroke.
Dr. Kumar's research centers on cell-type specific proteomics in neurodegenerative contexts, particularly leveraging TurboID proximity labeling to map molecular alterations in Alzheimer's disease and stroke models. His investigations target parvalbumin interneurons, astrocytes, and microglia, revealing metabolic vulnerabilities and neuroinflammatory pathways. Current projects emphasize multi-omics integration and machine learning for biomarker discovery, with direct implications for diagnostic tools and therapeutic targeting.
Analysis of his recent publication trajectory (2024-2025) shows concentrated innovation in plasma proteomics for stroke diagnostics, cellular subcompartment proteomics, and neuroimmune interactions. Key themes include distinguishing stroke mimics from transient ischemic attacks, identifying atrial fibrillation biomarkers in stroke patients, and characterizing Kv1.3 channel roles in neuroinflammation—demonstrating methodological rigor across in vivo models and clinical datasets.
Within the Rangaraju Lab, Dr. Kumar contributes to Yale's collaborative neuroscience ecosystem through the Yale Center for Experimental Neuroimaging and Clinical Neurosciences Imaging Center, focusing on proteomic signatures of early Alzheimer's pathology and ischemic injury. His work directly supports the department's mission in neurodegenerative disease research and clinical translation.