معرفی
Pradoldej (Bob) Sompol, PhD, is an Assistant Professor at the Sanders-Brown Center on Aging, University of Kentucky. He is also affiliated with the Department of Pharmacology and Nutritional Sciences. His research focuses on understanding the role of reactive astrocytes in age-related neurodegenerative diseases, particularly Alzheimer’s disease.
His research interests include:
- Reactive astrocytes and glial signaling
- Oxidative stress and mitochondrial dysfunction in neurodegeneration
- Neurovascular coupling and cerebrovascular pathology
- Calcineurin/NFAT signaling pathways
- Synaptic plasticity and network hyperexcitability
- Neuroprotective strategies using small molecules and natural compounds
The recent publication trends highlight a strong focus on molecular mechanisms in Alzheimer’s and traumatic brain injury models, with particular emphasis on astrocyte-mediated neuroinflammation, synaptic dysfunction, and therapeutic interventions targeting neuroprotection and neurogenesis. Techniques such as intravital imaging, electrophysiology, and behavioral assays are central to his research approach.
Scientific awards:
- No awards explicitly mentioned in the provided text.
Dr. Sompol actively leads a research program investigating neurodegenerative mechanisms using human postmortem tissue and transgenic animal models. While specific student mentees are not listed, his publications suggest collaborative mentoring in neuroscience and pharmacology. His lab has developed innovative models combining vascular and amyloid pathologies, contributing to a deeper understanding of mixed dementia etiologies. There is no mention of external grants, but his work implies funding support for advanced imaging and molecular studies.
His research team operates within the Sanders-Brown Center on Aging, a leading institution in aging and dementia research, and collaborates extensively across disciplines, particularly in pharmacology and neuroscience.
