معرفی
Pierre Thibault is a Full Professor (Professeur titulaire) at the Université de Montréal, holding dual affiliations in the Department of Chemistry (Faculty of Arts and Sciences) and the Department of Biochemistry and Molecular Medicine (Faculty of Medicine). He also serves as an associated professor at McGill University’s Department of Anatomy and Cell Biology. His research focuses on proteomics and bioanalytical mass spectrometry, with a particular emphasis on post-translational modifications, cancer biology, and immunopeptidomics. Thibault leads the Proteomics and Bioanalytical Mass Spectrometry Unit at the Institut de recherche en immunologie et en cancérologie (IRIC) and co-directs the Center for Advanced Proteomic and Chemogenomic Analyses (CAPCA).
Education: PhD in Analytical Chemistry from Université de Montréal (1988).
Research Expertise: Thibault’s work integrates advanced proteomic techniques to study cellular signaling pathways, protein modifications (e.g., phosphorylation, SUMOylation), and antigen presentation. His lab develops tools for identifying tumor-specific antigens and optimizing mass spectrometry-based analyses. Key projects include studying organelle biogenesis, cancer cell signaling, and immune mechanisms in diseases like Parkinson’s and leukemia.
Recent Articles Trends: His 2025 publications emphasize tumor antigen discovery in melanoma and lung cancer, leveraging unmutated genomic sequences for immunotherapy. He also explores microRNA regulation in renal injury and drug selectivity mechanisms. Earlier works (2024) highlight machine learning applications in immunopeptidomics and autophagy-driven antiviral responses.
Awards: Includes the Prix Urgel-Archambault (2018), Tony Pawson Award (2017), and Maxxam Prize (2012). Early career honors from the National Research Council of Canada (NRC) recognized his analytical mass spectrometry contributions (1988, 1996).
Grants & Collaborations: Leads or co-leads over 50 funded projects, including initiatives on tumor antigen discovery (IRSC), AI-driven pandemic response (PandemicStop-AI), and kidney fibrosis biomarkers. Collaborations span institutions like McGill University, IRIC, and the Michael J. Fox Foundation.
Labs & Teams: Directs the IRIC Proteomics Unit and CAPCA, fostering interdisciplinary research with teams in chemistry, bioinformatics, and clinical oncology. His group’s tools enable precision medicine approaches, such as identifying therapeutic vaccine targets for leukemia and ovarian cancer.
